Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 53, Issue 7, Pages 2719-2740Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm901137j
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Funding
- Cancer Therapeutics CRC
- Australian Government's Cooperative Research Centres Program
- NHMRC IRIISS [361646]
- Victorian State Government [01S]
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This report describes a number of substructural features which can help to identify compounds that appear as frequent hitters (promiscuous compounds) in many biochemical high throughput screens. The compounds identified by such substructural features are not recognized by filters commonly used to identify reactive compounds. Even though these substructural features were identified using only one assay detection technology, such compounds have been reported to be active from many different assays. In fact, these compounds are increasingly prevalent in the literature as potential starting points for further exploration, whereas they may not be.
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