Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 53, Issue 18, Pages 6758-6762Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm1004368
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Funding
- Jedlik Anyos program
- [NKFP-AI-2006-0069]
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NOX enzymes are the major contributors in many oxidative damage related diseases. Unfortunately, at present no specific NOX inhibitor is available. Here, we describe the discovery and development of novel NOX4 inhibitors. Compound libraries were tested in a cell-based assay as a primary screen, monitoring, H2O2 production. Twenty-four compounds inhibited NOX4 activity with low-micromolar IC50 values of which three were selected for further drug development.
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