Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 53, Issue 7, Pages 2998-3002Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm100078r
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [16570104]
- National Health and Medical Research Council
- Australian Research Council
- Federation Fellowship
- Italian Ministry of Instruction, University and Research
- Fondazione Cariplo
- Grants-in-Aid for Scientific Research [16570104] Funding Source: KAKEN
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With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.
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