Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 53, Issue 13, Pages 5054-5058Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm100476d
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- JSPS
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Mitotic kinesin spindle protein (KSP) is involved in the assembly of the bipolar spindle during cell division. On the basis of a common 2,3-fused indole substructure within the complex frameworks of terpendole E and other KSP inhibitors, the carbazoles with a bulky alkyl group were identified as a novel KSP inhibitory scaffold. Additionally, among several naturally occurring cell growth inhibitors with 2,3-fused indole structures, beta-carboline alkaloids, harman and harmine, showed moderate inhibition of KSP.
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