Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 53, Issue 21, Pages 7639-7646Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm1007825
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As part of our efforts to develop agents for CNS diseases, we have been focused on the 5-HT(6) receptor in order to identify potent and selective ligands for cognitive enhancement. Herein we report the identification of a novel series of 5-piperazinyl-3-sulfonylindazoles as potent and selective 5-HT(6) antagonists. The synthesis, SA R, and pharmacokinetic and pharmacological activities of some of the compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-l-yl)-1H-indazole (WAY-255315 or SAM-315) will be described.
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