Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 53, Issue 7, Pages 2766-2778Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm901860h
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Funding
- National Institutes of Health [R01 GM067958, T32 GM008715, HL081682, GM50388]
- American Heart Association
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Sphingosine 1-phosphate (S1P), a potent phospholipid growth and trophic factor, is synthesized in vivo by two sphingosine kinases. Thus these kinases have been proposed as important drug targets for treatment of hyperproliferative diseases and inflammation. We report here a new class of amidine-based sphingosine analogues that are competitive inhibitors of sphingosine kinases exhibiting varying degrees of enzyme selectivity. These inhibitors display K(I) values in the submicromolar range for both sphingosine kinases and, in cultured vascular smooth muscle cells, decrease S1P levels and initiate growth arrest.
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