Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 52, Issue 14, Pages 4087-4090Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm8015987
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Funding
- EU [018671]
- Drug Design for Cardiovascular Diseases: Integration of in Silico
- Vitro Analysis (CARDIO-WORKBENCH)
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Rac1 protein is implicated in several events of atherosclerotic plaque development and represents a new potential pharmacological target for cardiovascular diseases. In this paper we describe a pharmacophore virtual screening followed by molecular docking calculations leading to the identification of five new Rac1 inhibitors. These compounds were shown to be more effective than the reference compound INSC23766 in reducing the intracellular levels of Rac1-GTP, thus supporting this approach for the development of new Rac1 inhibitors.
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