Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 52, Issue 21, Pages 6519-6522Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm9012856
Keywords
-
Categories
Funding
- National Institutes Of Health [CA 101880]
Ask authors/readers for more resources
Cationic gold(I) complexes containing 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea (1), [AuL(1)](n+) (where L is Cl-, Br-, SCN-, PEt3, PPh3, or 1), derived from a class of analogous platinum(II) antitumor agents, have been synthesized. Unlike platinum, gold does not form permanent adducts with DNA, and its complexes are 2 orders of magnitude less cytotoxic in non-small-cell lung cancer cells than the most active platinum-based agent. Instead, several gold analogues show submicromolar and selective anti microbial activity against Mycobacterium tuberculosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available