Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 52, Issue 16, Pages 5009-5012Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm900725r
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4-Substituted piperidine-derived trisubstituted ureas are reported as highly potent and selective inhibitors for sEH. The SAR Outlines approaches to improve activity against sEH and reduce ion channel and CYP liability. With minimal off-target activity and a good PK profile, the benchmark 2d exhibited remarkable tit vitro ;and ex vivo target engagement. The customer entA-2d also elicited vasodilation effect in tat mesenteric artery.
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