Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 15, Pages 4834-4838Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm800167u
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Funding
- NCI NIH HHS [CA116846, R21 CA116846] Funding Source: Medline
- NIAID NIH HHS [R03 AI054615] Funding Source: Medline
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Novel furoxan-based nitric oxide (NO) releasing derivatives of oleanolic acid (OA) were synthesized for potential therapy of liver cancers. Six compounds produced high levels of NO in human hepatocellular carcinoma (HCC) cells and exhibited strong cytotoxicity selectively against HCC in vitro. Treatment with 8b or 16b significantly inhibited the growth of HCC tumors in vivo. These data provide a proof-in-principle that furoxan/OA hybrids may be used for therapeutic intervention of human liver cancers.
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