Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 12, Pages 3353-3356Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm800379d
Keywords
-
Categories
Ask authors/readers for more resources
The oxazolidinone antibacterials target the 50S subunit of prokaryotic ribosomes. To gain insight into their mechanism of action, the crystal structure of the canonical oxazolidinone, linezolid, has been determined bound to the Haloarcula marismortui 50S subunit. Linezolid binds the 50S A-site, near the catalytic center, which suggests that inhibition involves competition with incoming A-site substrates. These results provide a structural basis for the discovery of improved oxazolidinones active against emerging drug-resistant clinical strains.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available