Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 18, Pages 5498-5501Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm800785t
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Funding
- National Institutes of Health [HL62244, GM38060]
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Heparin, a widely used anticoagulant, is being rapidly displaced by low-molecular-weight heparins. Recently, certain lots of heparin have been associated with anaphylactoid-type reactions resulting from contamination with oversulfated chondroitin sulfate. This impurity has also contaminated low-molecular-weight heparins obtained by chemical and enzymatic depolymerization of heparin. The sensitivity of oversulfated chondroitin sulfate to five different depolynierization processes similar to ones used in preparing low-molecular-weight heparins is reported.
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