Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 7, Pages 2321-2325Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm7015705
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Constrained analogues of procaine were synthesized, and their inhibiting activity against DNMT1 was tested. Among them, the most potent compound, derivative 3b, was also able to induce a recognizable demethylation of chromosomal satellite repeats in HL60 human myeloid leukemia cells and thus represents a lead compound for the development of a novel class of non-nucleoside DNMT1 inhibitors.
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