Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 20, Pages 6256-6258Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm8007807
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Funding
- Department of Defense Breast Cancer Research Program [W81XWH-04-1-0688, DAMD1703-1-0175]
- National Cancer Institute [1R01CA120009]
- [MSM 6198959216]
- [GACR 303/08/P137]
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A series of three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) was prepared, confirmed by X-ray crystallography, and tested in human breast cancer MDA-MB-231 cells. Zinc and copper complexes, but not nickel complex, were found to be more active against cellular 26S proteasome than against purified 20S proteasome core particle. One of the possible explanations is inhibition of JAMM domain in the 19S proteasome lid.
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