Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 10, Pages 2883-2886Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm8002747
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The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl-N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of A beta fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect.
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