Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 23, Pages 7640-7644Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm800970b
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A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist 3. Modification based on the homology model of GPR120 led to the first GPR120-selective agonist 12. These results provide a basis for constructing new tools for probing the biology of GPR120 and for developing new candidate therapeutic agents.
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