Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 12, Pages 3349-3352Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm800279t
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An X-ray crystal structure is reported for the novel enhanced-affinity glucocorticoid agonist fluticasone furoate (FF) in the ligand binding domain of the glucocorticoid receptor. Comparison of this structure with those of dexamethasone and fluticasone propionate shows the 17 alpha furoate ester to occupy more fully the lipophilic 17 alpha pocket on the receptor, which may account for the enhanced glucocorticoid receptor binding of FF.
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