Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 5, Pages 1402-1405Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm7010854
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Funding
- NCI NIH HHS [CA36622] Funding Source: Medline
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Rapidly increasing experimental and clinical data provides evidence for the role of hypoxia inducible factor-1 (HIF-1) as a crucial mediator of tumor survival and progression. In our effort to identify inhibitors of the HIF-1 activation pathway, we screened fractions from marine invertebrates. Fractions from an extract of Petrosia (Strongylophora) strongylata potently inhibited the HIF-1 activation pathway. Strongylophorines 2, 3, and 8 isolated from the active fractions were found to be responsible for the HIF-1 inhibition with EC50 values of 8, 13, and 6 mu M, respectively.
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