4.7 Article

Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors

Journal

JOURNAL OF MEDICINAL CHEMISTRY
Volume 51, Issue 22, Pages 7049-7052

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jm801050k

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A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.

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