Genome-wide association study of HPV-associated cervical cancer in Japanese women

One of the important factors influencing the development of uterine cervical cancer is human papillomavirus infection in women. Usually, the infecting papillomavirus is eliminated from individuals; however, some retain the virus and this is believed to lead to the development of uterine cervical cancer. It is possible that virus elimination or persistent infection depends on an individual's genetic background. To identify single nucleotide polymorphisms associated with susceptibility to persistent infection or cervical cancer, a genome-wide association study was performed on 226 cases and 186 controls. Some of the single nucleotide polymorphisms showed a P-value < 10(-5); however, no polymorphisms that were significantly associated with susceptibility to cervical cancer were identified. J. Med. Virol. 86:1153-1158, 2014. (c) 2014 Wiley Periodicals, Inc.