Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 84, Issue 7, Pages 1084-1088Publisher
WILEY
DOI: 10.1002/jmv.23291
Keywords
respiratory syncytial virus; cytokines and chemokines; interleukin-17; innate immune responses
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Funding
- European Society for Pediatric Infectious Diseases (ESPID)
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Although Respiratory syncytial virus (RSV) bronchiolitis is the most important cause of hospital admission for infants during the winter season, the pathogenesis is largely unknown. Interleukin-17 (IL-17) concentrations were studied in nasopharyngeal aspirates from 21 non-ventilated and 17 ventilated infants admitted to hospital with RSV bronchiolitis at time of admission and discharge from the hospital. On admission, nasopharyngeal concentrations of most cytokines and chemokines were lower in non-ventilated infants than in ventilated infants, reaching statistical significance for Eotaxin, IL-1a, and IL-6. During course of disease, nasopharyngeal concentrations of most cytokines and chemokines decreased, reaching statistical significance for IL-6 and IP-10. However, nasopharyngeal IL-17 concentrations were higher at discharge than at admission in children with non-ventilated RSV disease (209101?pg/ml, P?=?0.008), a response pattern not observed in ventilated RSV patients nor for other cytokines or chemokines. It is speculated that local IL-17 production may be involved during convalescence from RSV bronchiolitis in non-ventilated patients by facilitating innate and adaptive antiviral immune responses. The role of IL-17 in the pathogenesis of RSV bronchiolitis is to be explored further. J. Med. Virol. 84: 10841088, 2012. (C) 2012 Wiley Periodicals, Inc.
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