Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 82, Issue 10, Pages 1782-1789Publisher
WILEY
DOI: 10.1002/jmv.21884
Keywords
human metapneumovirus; genotype; disease; severity; X-ray
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Funding
- Centre Hospitalier Universitaire of Dijon
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Human metapneumovirus is a cause of respiratory tract infections at all ages. Our objectives were to analyze the distribution of the A and B genotypes over 7 years in Dijon and to investigate a possible association between hMPV genotypes and disease severity. During 2002-2009, we genotyped the 100 isolates from children <3 years old with hMPV. Phylogenetic analysis indicated a change in the distribution of hMPV genotype over the years. Severity was then measured by detailed clinical evaluation. The hospitalization rate was greater when genotype B was involved 72.5% versus 53.3% (P = 0.054). Those infected with genotype B tended to have a higher clinical score, as measured by Vicente et al. [2006] (P = 0.07). We showed that, although clinical severity is not clearly associated with hMPV genotype in this study, pathological signs on chest X-ray were observed more often in B subgroup (P < 0.01). J. Med. Virol. 82:1782-1789, 2010. (C) 2010 Wiley-Liss, Inc.
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