Journal
JOURNAL OF MEDICAL MICROBIOLOGY
Volume 59, Issue 5, Pages 511-520Publisher
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.017715-0
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Funding
- National Center for Research Resources (NCRR) [KL2 RR024138]
- National Institutes of Health (NIH) [R42 AI058659]
- NIH roadmap for research
- Yale Child Health Research Center [K12 HD001401]
- Patrick and Catherine Weldon Donaghue Medical Research Foundation
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Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen capable of acutely infecting or persistently colonizing susceptible hosts. P. aeruginosa colonizes surfaces in vitro by either biofilm formation or swarming motility. The choice of behaviour is influenced by the physical properties of the surface and specific nutrient availability, and subject to regulatory networks that also govern type 2 and type 3 protein secretion. Biofilm formation by clinical isolates has been well-studied However, the swarming behaviour of human isolates has not been extensively analysed We collected isolates from 237 hospitalized patients without cystic fibrosis and analysed motility and secretion phenotypes of each isolate We found biofilm formation and swarming to be negatively associated, while swarming was positively associated with the secretion of both proteases and type 3 exoenzymes Most isolates were capable of type 3 secretion and biofilm formation, even though these traits are considered to favour distinct modes of pathogenesis Our data demonstrate that while clinical isolates display diverse motility, biofilm and secretion phenotypes, many of the predicted relationships between swarming motility and other phenotypes observed in laboratory strains also hold true for bacteria isolated from human patients
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