Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 34, Issue 2, Pages 214-218Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000000539
Keywords
tuberculous meningitis; tuberculous pseudoabscess; thalidomide; tumor necrosis factor-alpha
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Funding
- South African National Research Foundation
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Neurologic tuberculous pseudoabscesses that clinically progress despite conventional antituberculosis therapy may be responsive to adjuvant thalidomide, a potent tumor necrosis factor-a inhibitor. In this study, the addition of thalidomide provided substantial clinical benefit in the majority of patients, and magnetic resonance imaging evolution of lesions from early-stage T2 bright with edema to T2 black represented a marker of cure.
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