Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 26, Issue 13, Pages 1332-1336Publisher
INFORMA HEALTHCARE
DOI: 10.3109/14767058.2013.784741
Keywords
Intra-uterine inflammation; neonatal morbidity; placenta; preterm birth
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Funding
- Charles University in Prague, Faculty of Medicine, Hradec Kralove, Czech Republic [PRVOUK P37/10]
- Faculty Hospital in Hradec Kralove (long-term organization development plan)
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Objective: To determine the impact of histological chorioamnionitis (HCA) and funisitis on neonatal outcome in preterm prelabor rupture of membranes (PPROM) pregnancies. Methods: Women with PPROM between 24+0 to 36+6 weeks of gestation, admitted to the Department of Obstetrics and Gynecology at the University Hospital Hradec Kralove in the Czech Republic, between July 2008 and October 2010, were enrolled in the study (n = 231). Results: The incidence of early-onset sepsis (EOS) differed significantly in neonates born to women with and without HCA, after adjustment for gestational age (11% versus 1%, p = 0.011). The incidence of EOS in neonates was also significantly different, after adjustment for gestational age, in cases with and without funisitis (18% versus 4%, p = 0.002). The same was also found for retinopathy of prematurity (ROP) cases with and without funisitis (23% versus 4%, p = 0.014), after adjustment for gestational age. Conclusions: HCA and funisitis increase the risk of adverse perinatal outcome in PPROM pregnancies.
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