Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 26, Issue 9, Pages 889-899Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2013.765849
Keywords
Gestational diabetes mellitus; 25-hydroxyvitamin D; preeclampsia; pregnancy; preterm birth; small-for-gestational age; vitamin D
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Funding
- Canadian Institutes of Health Research (CIHR) RCT Mentoring Program
- Junior Scholar award from the Fonds de Recherche en Sante du Quebec (FRSQ)
- CIHR New Investigator award
- CIHR Canada Research Chair award
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Objective: To estimate the associations between maternal vitamin D status and adverse pregnancy outcomes. Study design: We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to October, 2012 using the following keywords: vitamin D and status or deficiency or insufficiency and pregnancy. A systematic review and meta-analysis were conducted on observational studies that reported the association between maternal blood vitamin D levels and adverse pregnancy outcomes including preeclampsia, gestational diabetes mellitus (GDM), preterm birth or small-for-gestational age (SGA). Results: Twenty-four studies met the inclusion criteria. Women with circulating 25-hydroxyvitamin D [25(OH)D] level less than 50 nmol/l in pregnancy experienced an increased risk of preeclampsia [odds ratio (OR) 2.09 (95% confidence intervals 1.50-2.90)], GDM [OR 1.38 (1.12-1.70)], preterm birth [OR 1.58 (1.08-2.31)] and SGA [OR 1.52 (1.08-2.15)]. Conclusion: Low maternal vitamin D levels in pregnancy may be associated with an increased risk of preeclampsia, GDM, preterm birth and SGA.
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