Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 27, Issue 6, Pages 621-624Publisher
INFORMA HEALTHCARE
DOI: 10.3109/14767058.2013.825600
Keywords
Factor VIII/IX; haemophilia; intracranial bleeding; neonate; prematurity
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Funding
- Central Laboratory of the University Hospital Wurzburg
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Haemophiliacs and extremely premature infants are both at an increased risk for intracranial haemorrhage; both conditions might be further elevating the risk. We report a case of a very immature preterm-infant of 26 gestational weeks (birth weight 635 g) with severe haemophilia A. Furthermore, we provide an overview of the published literature on this subject matter. Until now, deficiency of factor VIII or IX as a potential risk factor for ICH in preterm infants remains controversial. However, prophylactic substitution of factor VIII or IX in preterm infants with haemophilia may minimize the risk of bleeding complications and neurologic sequelae.
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