Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 25, Issue 9, Pages 1730-1734Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2012.663022
Keywords
China; gestational age; hospital-based monitory; neural tube defect; prevalence
Categories
Funding
- Ministry of Science and Technology of China [2006BA 105A01]
- Chinese Ministry of Health [QT2003-009, 05wsb-02]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0935]
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Objective: To determine the prevalence of pregnancies with neural tube defects (NTDs) in China between 2006 and 2008 and to find a better representative monitoring gestational age for total prevalence of NTDs by comparing the prevalence at or greater than 20, 22 or 28 weeks of gestation (abbreviated as P20, P22 and P28, respectively). Methods: The data were retrieved from the National Birth Defects Monitoring Network in China (the Network). All births were monitored on the prevalence of NTDs during the entire gestation period of 2006-2008. Results: The P28 only represents 34.6% of anencephaly, 70.8% of spina bifida, 53.3% of encephalocele and 53% of the combination of the three types of NTDs during the entire pregnancy. The P20 represents 75.8%, 94.7%, 86% and 85.4% in the above-mentioned categories, respectively. Of the NTDs diagnosed prenatally before 28 weeks of gestation, 45.3% were terminated electively. Conclusions: The P28 underrepresented 65.4% of anencephaly, 29.2% of spina bifida, 46.7% of encephalocele and 47% of the combined NTDs. The prevalence of NTDs that occurred at or greater than 20 weeks of gestation was more accurate than that at or greater than 28 weeks of gestation.
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