Journal
PEDIATRIC ALLERGY AND IMMUNOLOGY
Volume 26, Issue 1, Pages 25-33Publisher
WILEY
DOI: 10.1111/pai.12330
Keywords
birth cohort; infants; quality of life; respiratory virus; rhinitis
Categories
Funding
- Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme - Singapore Ministry of Health's National Medical Research Council (NMRC) [Singapore-NMRC/TCR/004-NUS/2008, NMRC/CSA/022/2010, NMRC/CIRG/1344/2012]
- NRF CREATE Programme [NRF370062-HUJ-NUS -PROJECT 10]
- NUHS Cross-Dept
- National Institute for Health Research through the NIHR Southampton Biomedical Research Centre
- MRC [MC_UU_12011/4] Funding Source: UKRI
- Medical Research Council [MC_UU_12011/4] Funding Source: researchfish
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BackgroundRhinitis is common in early childhood, but allergic rhinitis is considered a later manifestation of the atopic march. This study aimed to evaluate rhinitis (allergic and non-allergic) in the first 18months of life, its link with other atopic manifestations and the role of respiratory viruses. MethodsSubjects (n=1237) of the Singapore GUSTO birth cohort were followed up quarterly until 18months of age with questionnaires to screen for rhinitis symptoms lasting at least 2wk and with monthly calls to positive subjects to detect prolonged/recurrent rhinitis symptoms (total duration 4wk). Anterior nasal swabbing for molecular-based virus detection was conducted during these visits and near (within a month) rhinitis episodes. Skin prick testing to common environmental and food allergens was conducted at the 18month visit. ResultsProlonged/recurrent rhinitis was significantly associated with history of parental atopy (mother: aOR=2.17; father: aOR=1.82) and atopic comorbidities of eczema (aOR=2.53) and wheeze (aOR=4.63) (p<0.05), though not with allergen sensitization. Although the frequency of nasal respiratory virus detection during scheduled quarterly visits did not differ between prolonged/recurrent rhinitis and matched controls (p>0.05), virus detection was higher in swabs obtained within a month following rhinitis episodes in prolonged/recurrent rhinitis subjects compared with scheduled visits (adjusted p=0.04). ConclusionsBased on the duration of rhinitis symptoms, this study defined a subset of early childhood rhinitis which was associated with atopic predisposition and comorbidities. Persistent respiratory viral shedding may contribute to the symptomatology. Whether this entity is a precursor of subsequent childhood allergic rhinitis will require longer follow-up.
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