Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 25, Issue 2, Pages 189-192Publisher
INFORMA HEALTHCARE
DOI: 10.3109/14767058.2011.557107
Keywords
Chemotherapy; anthracyclines; pregnancy; cardiac toxicity; newborn
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Due to the low occurrence of cancer during pregnancy, limited data are available about outcome of infants exposed to chemotherapy in utero. We report the case of a newborn who developed transient ventricular hypocinesia and late-onset infection after in utero exposure to four epirubicin cycles for pregnancy-associated breast cancer. Moreover, we provide an overview of literature on neonatal outcome after anthracyclines-based chemotherapy regimen during pregnancy. Existing data support use of anthracyclines, as few cases of fetal cardiac toxicity were reported and most of short-term complications were transient. Need for prospective collection of data and longer follow-up is highly recognized.
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