Journal
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Volume 24, Issue 1, Pages 257-265Publisher
SPRINGER
DOI: 10.1007/s10856-012-4781-5
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The objective of this study was to determine a silk-collagen fiber ratio for an anterior cruciate ligament (ACL) reconstruction composite scaffold device. Composite fiber scaffolds with silk volumes a parts per thousand yen14 % and collagen volume < 86 % demonstrated comparable or greater initial ultimate tensile stress relative to the human ACL. Silk scaffolds implanted subcutaneously and intraarticularly in rabbits demonstrated an 84 and 92 % reduction in strength with a 26 and 22 % reduction in volume after 8 weeks, respectively. The mechanical degradation findings of this preliminary study suggest that a composite scaffold with an initial UTS value of at least 129 MPa, or roughly a 48:52 silk to collagen volume ratio meets the minimal mechanical requirements necessary to proceed to a functional ACL reconstruction study in vivo.
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