Magnetic bioactive glass ceramic in the system CaO-P2O5-SiO2-MgO-CaF2-MnO2-Fe2O3 for hyperthermia treatment of bone tumor

Magnetic bioactive glass ceramic (MG) in the system CaO-SiO2-P2O5-MgO-CaF2-MnO2-Fe2O3 for hyperthermia treatment of bone tumor was synthesized. The phase composition was investigated by XRD. The magnetic property was measured by VSM. The in vitro bioactivity was investigated by simulated body fluid (SBF) soaking experiment. Cell growth on the surface of the material was evaluated by co-culturing osteoblast-like ROS17/2.8 cells with materials for 7 days. The results showed that MG contained CaSiO3 and Ca-5(PO4)(3)F as the main phases, and MnFe2O4 and Fe3O4 as the magnetic phases. Under a magnetic field of 10,000 Oe, the saturation magnetization and coercive force of MG were 6.4 emu/g and 198 Oe, respectively. After soaking in SBF for 14 days, hydroxyapatite containing CO3 (2-) was observed on the surface of MG. The experiment of co-culturing cells with material showed that cells could successfully attach and well proliferate on MG.