Journal
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Volume 20, Issue 12, Pages 2375-2383Publisher
SPRINGER
DOI: 10.1007/s10856-009-3810-5
Keywords
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Funding
- National Nature Science Foundation of China [30600149]
- science research foundation of ministry of Health & United Fujian Provincial Health and Education [WKJ 2008-2-037]
- Project of Education Department [209061, JA08030]
- Fujian Provincial Department of Science and Technology [2006I0015]
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Hydroxyapatite (HA)/polycaprolactone (PCL)-chitosan (CS) composites were prepared by melt-blending. For the composites, the amount of HA was varied from 0% to 30% by weight. The morphology, structure and component of the composites were evaluated using environmental scanning electron microscope, X-ray diffraction and Fourier transform infrared spectroscope. The tensile properties were evaluated by tensile test. The bioactivity and degradation property were investigated after immersing in simulated body fluid (SBF) and physiological saline, respectively. The results show that the addition of HA to PCL-CS matrix tends to suppress the crystallization of PCL but improves the hydrophilicity. Adding HA to the composites decreases the tensile strength and elongation at break but increases the tensile modulus. After immersing in SBF for 14 days, the surface of HA/PCL-CS composites are covered by a coating of carbonated hydroxyapatite with low crystallinity, indicating the excellent bioactivity of the composites. Soaking in the physiological saline for 28 days, the molecular weight of PCL decreases while the mass loss of the composites and pH of physiological saline increase to 5.86% and 9.54, respectively, implying a good degradation property of the composites.
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