Journal
PATHOLOGY & ONCOLOGY RESEARCH
Volume 22, Issue 1, Pages 57-65Publisher
SPRINGER
DOI: 10.1007/s12253-015-9967-y
Keywords
Praziquantel; Aspirin; Opisthorchis viverrini; N-nitrosodimethylamine; Cholangiocarcinoma; Syrian hamster
Funding
- Faculty of Medicine at Khon Kaen University [I56203]
- Khon Kaen University [KKU55]
- Capital development capability in postgraduate research education, faculty of Medicine, Khon Kaen University
- Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission through the Health Cluster (SHep-GMS)
- TRF [RTA5580004]
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Opisthorchiasis is one of the major risk factors for cholangiocarcinoma (CCA) in northeastern Thailand. An effective drug for killing this parasite is praziquantel. Recently, several reports have shown that with frequent use, praziquantel may itself be a CCA risk and can cause liver cell damage from an immunopathological response after parasite death. Aspirin has many properties including anti-inflammation and anti-cancer. Therefore, we use of aspirin (As) and praziquantel (Pz) to improve hepatobiliary system function in hamsters infected with Opisthorchis viverrini (OV) and or administered N-nitrosodimethylamine (ND). Livers of OVNDAsPz, appeared healthy macroscopically, suggesting slow progression of cholangiocarcinoma evident by extent of fibrosis and bile duct cell proliferation was less than OVND although aggregations of inflammatory cells remained. Proliferating cell nuclear antigen (PCNA), cytokeratin 19 (CK19), and cancer antigen (CA19-9) staining were strongly positive in OVND, but were only slight in OVNDAs. Moreover, OVNDAsPz, appeared a few inflammatory infiltrations, bile duct proliferation, fibrosis and CCA area than the OVNDAs group. Thirty seven point five percent of hamster in this group could not develop CCA. These findings suggest that using aspirin combination with praziquantel treatment can improve the hepatobiliary system after O. viverrini infection and reduce the risk of CCA.
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