Journal
PATHOLOGY
Volume 47, Issue 6, Pages 526-532Publisher
ELSEVIER SCIENCE BV
DOI: 10.1097/PAT.0000000000000276
Keywords
Cardia; Chinese; gastric cancer; Helicobacter pylori
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Funding
- Science and Technology Development Project of the Nanjing City in China [ZKX05013, ZKX07011]
- Nanjing Drum Tower Hospital, Nanjing, China
- Department of Veterans Affairs Office of Research and Development through a Career Development Award
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Clinicopathological characteristics of small gastric carcinoma have not been well defined in Chinese patients. The aim of this study was to investigate and compare small proximal (PGC, n = 111) with distal (DGC, n = 202) gastric carcinoma in 313 consecutive surgically resected small (<= 2 cm) gastric carcinomas diagnosed with the WHO criteria. PGC patients were significantly older (average age 63 years versus 59 in DGCs) with a male/female ratio of 3:1. Most tumours were clustered along the lesser curvature (74% in PGCs and 65% in DGCs). Compared to DGCs, PGCs showed a protruded gross pattern significantly more frequently and were significantly better differentiated with a significantly wider histomorphological spectrum. Surprisingly, PGCs were composed of significantly fewer signet-ring cell carcinomas (1% versus 16% in DGCs) but were significantly more deeply invasive, compared to DGCs. Lymph node metastasis was detected in 23% overall, but was significantly less frequent in PGCs (16%) than in DGCs (26%) (p < 0.05). However, the difference in survival between the two groups was not statistically significant. Our results demonstrate that in Chinese patients, PGCs display distinct clinicopathological characteristics, compared to DGCs.
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