Journal
PATHOBIOLOGY
Volume 82, Issue 3-4, Pages 133-141Publisher
KARGER
DOI: 10.1159/000430464
Keywords
Breast cancer; Calpain; Calpastatin; Prognosis; Proteases
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Funding
- Breast Cancer Campaign
- University of Nottingham Vice-Chancellors Scholarship for Research Excellence
- Breast Cancer Research Trust
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The calpains are a family of intracellular cysteine proteases that function in a wide array of cellular activities, including cytoskeletal remodelling, survival and apoptosis. The ubiquitously expressed micro (mu)-calpain and milli (m)-calpain are archetypal family members that require calcium for function and can be inhibited by their endogenous inhibitor calpastatin. This review describes the role of the calpain system in the prognosis of breast cancer and disease progression, in addition to the role of the calpain system in the response to breast cancer treatments, including chemotherapeutic, endocrine and targeted therapies. (C) 2015 S. Karger AG, Basel
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