4.3 Article

Polymer-gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(III) complexes

Journal

JOURNAL OF MATERIALS CHEMISTRY
Volume 22, Issue 40, Pages 21382-21386

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm34999j

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Funding

  1. Australian Research Council (ARC) [DP110104251]
  2. Australian Postdoctoral Fellowship
  3. Actions de Recherche Concertee program [AUWB-2010-10/15-UMONS-5]
  4. FNRS program
  5. ENCITE program
  6. European Regional Development Fund
  7. Walloon Region

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We present a new synthetic strategy to produce Gd(III)-decorated gold nanoparticles (AuNPs) for potential use as bimodal contrast agents (CA) for computed X-ray tomography (CT) and magnetic resonance imaging (MRI). The hybrid AuNPs exhibit high molar relaxivities (>12 000 mM(-1) s(-1) per particle), indicative of highly efficient CT/MRI CAs.

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