Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 22, Issue 4, Pages 1352-1357Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm14418a
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Funding
- National Cancer Institute of the National Institutes of Health
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Hydrogel materials are finding use in heavy metal ion detection and remediation. MBHP is a twenty-residue peptide capable of undergoing hydrogelation in response to heavy metal ion binding. The unstructured peptide binds monomethylarsonous acid, Pb2+, Zn2+, Cd2+ or Hg2+ and subsequently folds into an amphiphilic beta-hairpin that rapidly self-assembles into a beta-sheet rich fibrillar network as shown by CD spectroscopy and transmission electron microscopy. LCMS shows that MBHP binds metal ions with a 1 : 1 stoichiometry. Oscillatory rheology indicates that moderately rigid hydrogels are formed as a result of metal ion binding, peptide folding and ultimate self-assembly with storage moduli (G') ranging from similar to 1000-4000 Pa.
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