Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 22, Issue 2, Pages 660-665Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm13563e
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Funding
- Medical Research Council
- Leverhulme Trust
- University of Nottingham
- Medical Research Council [G0801741] Funding Source: researchfish
- MRC [G0801741] Funding Source: UKRI
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We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL(-1) triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivo imaging studies.
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