Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 22, Issue 18, Pages 9041-9045Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm30325f
Keywords
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Funding
- World Premier International Research Center Initiative (WPI), MEXT, Japan
- [20226015]
- [21241023]
- Grants-in-Aid for Scientific Research [20226015, 21241023, 22108503, 24108703] Funding Source: KAKEN
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In our study, water dispersible magnetite (Fe3O4) nanoparticles were continuously synthesized in water under high temperature and pressure in the presence of 3,4-dihydroxyhydrocinnamic acid (DHCA) by using a tubular flow reactor. The prepared Fe3O4 nanoparticles were well dispersed in water because the surfaces of the nanoparticles were fully covered by DHCA molecules and the -COOH groups in the DHCA molecules were exposed to the surrounding water. Cytokines such as IL-12 and TNF-alpha were not produced from the dendritic cells of mice by co-incubation with our synthesized Fe3O4. This indicates that the synthesized Fe3O4 had no immune stimulating property for the dendritic cells of the mouse. Therefore, our synthesized Fe3O4 nanoparticles are suitable for biological applications such as magnetic resonance imaging contrast agents and carriers for drug and gene delivery, and in areas such as hyperthermia therapy for cancer, biosensors, and tissue engineering.
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