Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 22, Issue 11, Pages 4623-4626Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm16702f
Keywords
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Funding
- Ministry of Science and Technology of China [2011CB606202]
- Fundamental Research Funds for the Central Universities [20102030101000038, 201120302020007]
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Porphyrin containing capsules with light-response were fabricated via Layer-by-Layer (LbL) assembly of two biocompatible polymers, chitosan (CHI) and 5-(4-aminophenyl)-10,15,20-triphenyl-porphyrin (APP) graft polyaspartic acid (PASP-g-APP), on CaCO3 particles. FITC labeled dextran (FITC-Dex) was encapsulated in the core as a model drug. With CaCO3 particles removal by EDTA, hollow capsules loaded with FITC-Dex were obtained. The capsules could degrade and release FITC-Dex with light illumination due to the reactive oxygen species (ROS) produced by porphyrin. Confocal laser scanning microscopy (CLSM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) were used to characterize the capsules. The degradation behavior of the capsules was studied with CLSM and TEM.
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