Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 22, Issue 12, Pages 5615-5621Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2jm15489g
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Funding
- National Basic Research Program of China (973 Program) [2011CB707905]
- Shanghai Rising-Star Program [10QH1402800]
- National Nature Science Foundation of China [51072212]
- Science and Technology Commission of Shanghai [11nm0506500]
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Hyaluronic acid-conjugated mesoporous silica nanoparticles (MSNs-HA) have been synthesized via a facile amidation reaction. This novel strategy can efficiently solve the agglomeration problem of MSNs in physiological fluids. The cellular experiments showed that MSNs-HA is capable of selectively targeting specific cancer cells over-expressing the CD44 protein, leading to rapid and concentration-dependent uptake by the cancer cells through the receptor-mediated endocytosis mechanism. In contrast, no selective targeting of MSNs-HA can be found to the CD44 low-expressing cells, such as MCF-7 and L929 cells. The hydrophobic camptothecin (CPT) drug was encapsulated into MSNs-HA, which showed enhanced cytotoxicity to the Hela cells compared to both free CPT and CPT-loaded MSNs-HA in the presence of excess free HA.
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