Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 21, Issue 9, Pages 3037-3045Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0jm02863k
Keywords
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Funding
- National Natural Science Foundation of China [50823007, 50972154, 50972092]
- National 863 plans projects [2007AA03Z317]
- CASKJCX Projects [KJCX2-YW-210, KJCX2-YW-M02]
- Science and Technology Commission of Shanghai [10430712800, 10QH1402800, 09R21416500]
- China Postdoctoral Science Foundation [20090450740]
- Special Foundation of China Postdoctoral Science Foundation [201003282]
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Rattle-type magnetic mesoporous silica nanospheres (RMMSNs) with a magnetic core and a mesoporous silica shell were prepared, and then the surface properties of the nanospheres were modified with biocompatible polymer poly(ethylene glycol) (PEG) and cancer-cell-specific ligand folic acid (FA), with the aim of specifically targeting cancer cells. Combined Prussian blue staining, magnetic resonance imaging, and high-resolution sector field inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis revealed that the obtained RMMSN-PEG/FA nanocomposite can specifically target cancer cells over-expressing FA receptors (FRs). The nanocomposites displayed very low in vitro toxicity and negligible hemolytic activity, which is in favor of further biological applications. Water-insoluble anticancer drug docetaxel was loaded into the surface-modified RMMSNs and delivered into human cancer cells via cell uptake. Surface conjugation with cancer-specific targeting agent FA increased the uptake into cancer cells that over-express FRs. In addition, after intravenous injection, the RMMSN-PEG/FA nanocomposite could be transported to the designated organs under an external magnetic field. Findings from this study suggest that the RMMSN-PEG/FA could be used as a platform for simultaneous imaging and therapeutic applications.
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