4.3 Article

Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands

Journal

JOURNAL OF MATERIALS CHEMISTRY
Volume 21, Issue 9, Pages 3037-3045

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0jm02863k

Keywords

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Funding

  1. National Natural Science Foundation of China [50823007, 50972154, 50972092]
  2. National 863 plans projects [2007AA03Z317]
  3. CASKJCX Projects [KJCX2-YW-210, KJCX2-YW-M02]
  4. Science and Technology Commission of Shanghai [10430712800, 10QH1402800, 09R21416500]
  5. China Postdoctoral Science Foundation [20090450740]
  6. Special Foundation of China Postdoctoral Science Foundation [201003282]

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Rattle-type magnetic mesoporous silica nanospheres (RMMSNs) with a magnetic core and a mesoporous silica shell were prepared, and then the surface properties of the nanospheres were modified with biocompatible polymer poly(ethylene glycol) (PEG) and cancer-cell-specific ligand folic acid (FA), with the aim of specifically targeting cancer cells. Combined Prussian blue staining, magnetic resonance imaging, and high-resolution sector field inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis revealed that the obtained RMMSN-PEG/FA nanocomposite can specifically target cancer cells over-expressing FA receptors (FRs). The nanocomposites displayed very low in vitro toxicity and negligible hemolytic activity, which is in favor of further biological applications. Water-insoluble anticancer drug docetaxel was loaded into the surface-modified RMMSNs and delivered into human cancer cells via cell uptake. Surface conjugation with cancer-specific targeting agent FA increased the uptake into cancer cells that over-express FRs. In addition, after intravenous injection, the RMMSN-PEG/FA nanocomposite could be transported to the designated organs under an external magnetic field. Findings from this study suggest that the RMMSN-PEG/FA could be used as a platform for simultaneous imaging and therapeutic applications.

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