4.3 Article

Silver(I)-glutathione biocoordination polymer hydrogel: effective antibacterial activity and improved cytocompatibility

Journal

JOURNAL OF MATERIALS CHEMISTRY
Volume 21, Issue 48, Pages 19214-19218

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm13693c

Keywords

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Funding

  1. National Natural Science Foundation for Distinguished Youth Scholars of China [21025310]
  2. National Natural Science Foundation of China [20901019, 20973047, 91027011]
  3. National Research Fund for Fundamental Key Project [2009CB930400]
  4. China-Korea Joint Research Project [2010DFA51700]
  5. Chinese Academy of Sciences

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A Ag(I)-glutathione biocoordination polymer hydrogel is fabricated and further cross-linked by Ca2+ ions. Compared with commercial silver sulfadiazine cream, the cross-linked Ag(I)-glutathione hydrogel exhibits effective antibacterial activity and improved cytocompatibility, which represents the first antibacterial hydrogel based on biocoordination polymers and has potential application in the biomedical field, e. g., burn wound dressings.

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