Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 21, Issue 28, Pages 10252-10260Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1jm10602c
Keywords
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Funding
- JST
- JSPS [18710093, 19700400, 20350052, 21106506]
- MEXT
- Grants-in-Aid for Scientific Research [18710093, 21106506, 20350052, 19700400] Funding Source: KAKEN
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Investigations into the interfaces between synthetic polymers and biomolecules are important in the biomedical materials field. Over the past decade, combinatorial biotechnologies such as the phage display and cell-surface display methods, in which random peptide libraries are displayed on phage bodies and cell surfaces, have been utilized to identify oligopeptides that specifically recognize the surfaces of artificial materials. The resulting peptides were chemically and biotechnologically utilized as novel functional nanomaterials. In this article, our recent progress in the identification and applications of polymer-binding peptides is reviewed. We show that various nanostructures of synthetic polymers can be the specific targets of biologically identified peptides, and that the peptides can be utilized in polymer science and technology.
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