Journal
PARKINSONISM & RELATED DISORDERS
Volume 21, Issue 10, Pages 1269-1272Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2015.08.010
Keywords
Parkinson's disease; Nocturnal immobility; Supine; Sleep position; Sleepiness; Sleep-disordered breathing
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Background: Impaired nocturnal mobility is a well-known problem in Parkinson's disease (PD), and clinical experience suggests a predominance of supine body position during sleep. However, this assumption - and potential consequences still awaits objective validation by a polysomnography-based and adequately controlled study. Methods: Clinical and polysomnographical analysis of 80 consecutive PD patients and 80 control subjects carefully matched for age, sex, body mass index and apnea-hypopnea index. Results: PD patients slept twice as much in supine position than control subjects (62.2 +/- 32.9% vs. 34.2 +/- 28.5%, p < 0.001). In PD, but not in control subjects, more supine sleep correlated with fewer changes in body position (rho = -0.434, p < 0.001). Longer PD disease duration was an independent predictor of more supine sleep in multiple linear regression analysis (beta = 0.389, p < 0.001); conversely, more supine sleep was associated with higher apnea-hypopnea index and daytime sleepiness. Conclusions: We confirmed that supine sleep is common in PD, and increases with longer disease duration. Our findings indicate that supine sleep may contribute to the overall disease burden by deteriorating sleep-disordered breathing and daytime vigilance. (C) 2015 Elsevier Ltd. All rights reserved.
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