4.3 Article

Fluorescent nanoparticles for ratiometric pH-monitoring in the neutral range

Journal

JOURNAL OF MATERIALS CHEMISTRY
Volume 20, Issue 8, Pages 1475-1482

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b918427a

Keywords

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Funding

  1. Deutsche Forschungs-gemeinschaft [MO 1062/5-1, MO 1062/6-1]
  2. European Union [MTKD-CT-2005-029554]

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This article describes the synthesis and characterisation of poly(acrylamide) nanoparticles (NPs) with a covalently immobilised pH-sensitive fluorophore. With a pK(a) of 6.7, good photostability, emission in the visible spectral range and large Stokes' shift the naphthalimide-based pH-indicator is well suited for bio-analytical applications. Additionally, the nanosensors contain a pH-insensitive reference fluorophore that allows the ratiometric monitoring of pH e.g. inside living cells. In order to enhance the cellular uptake and endosomal escape of the beads, novel core-shell nanoparticles bearing a positive z-potential are synthesised and evaluated.

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