Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 20, Issue 25, Pages 5251-5259Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b923184f
Keywords
-
Funding
- Kent State University [B-9119]
- Malvern Instruments
Ask authors/readers for more resources
A simple and improved aqueous synthetic procedure using flash heating for preparing biocompatible Prussian blue nanoparticles (PBNPs) with the single-crystal-like feature was developed. This method entailed the use of citric acid as a chelator to complex ferric ions in the precursor and as an in situ capping agent to prevent the PB nanoparticles formed in solution from aggregation. The citrate-coated PBNPs, which can be surface functionalized with small molecules, were readily internalized by cells and exhibited no detectable cytotoxicity. Furthermore, such nanoparticles do not trigger the production of reactive oxygen species (ROS) in cells via the Fenton reaction. The potential of using such PBNPs as an effective T-1-weighted cellular MRI contrast agent has also been demonstrated. These properties suggest that PBNPs are an attractive dual purpose nanoplatform for developing the next generation of nanoparticle-based T-1-weighted MRI contrast agents as well as delivery vehicles for small molecules.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available