Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 19, Issue 11, Pages 1576-1582Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b813156b
Keywords
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Funding
- MICINN for RC [MAT2006-02394, BFU2006-00767/BMC, 200660F01, 200760I009, S-0505/PPQ-0316]
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This work describes a simple procedure for preparation of chitosan (CHI) scaffolds containing ciprofloxacin (CFX) anhydrous crystals. The capability of CHI scaffolds to control the CFX crystal size and to preserve the anhydrous crystal habit even after long term storage was useful for the development of drug delivery systems (e.g., CFX/CHI scaffolds) exhibiting a novel way to control the kinetic release, that is, by the solubility/hydration ratio of CFX anhydrous crystals depending on their crystal size rather than by typical mechanisms based on swelling, hydration and/or erosion of the polymer acting as carrier.
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