Journal
JOURNAL OF MATERIALS CHEMISTRY
Volume 19, Issue 29, Pages 5071-5077Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b822264a
Keywords
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Funding
- U. S. Department of Health and Human Services, George Mason University
- Italian Ministry of Public Health
- U. S. Department of Energy [DE-FC5204NA25455]
- NIH [1R21CA37706-01]
- NATIONAL CANCER INSTITUTE [R21CA137706] Funding Source: NIH RePORTER
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The incorporation of affinity baits into N-isopropylacrylamide-hydrogel-based nanoparticles offers a novel technology that addresses the major analytical challenges of disease biomarker discovery. In solution in complex biologic fluids (e. g. blood or urine), core-shell bait-containing nanoparticles can perform three functions in one step: (a) sieve molecules according to size, (b) sequestrate and concentrate target analytes, and (c) protect analytes from degradation.
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